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Approach Phase 2b trial arm Duration 24 weeks Review Point Week 12 and 24 Notes METAOD006 (OPTIONS) used 24 weeks at oral doses 0.25, 0.5, or 1 mg/day in 502 obese adults

The improvements could be due to placebo effect or the invasive procedure itself (cystoscopy), and subtle side effects might have gone unnoticed in such a small sample

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1 Third, although this disease state is not fully understood, the possibility of preventing long-term sequelae without inducing more harm would be in the best interest of the patient

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