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Immunohistochemistry and advanced imaging techniques Tissue sections underwent immunohistochemical staining using primary antibodies (CD68, F4/80, Ki67, PCNA, CD31, VEGFR2, CK-18, -Tubulin, Mucin5AC, Aggrecan, COL2

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10.1006/jsbi.2000.4270 J

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However, the main limitation of these studies is the pure diffusion hypothesis, which still needs to be confirmed by further research

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Recent studies strongly support the notion that mitochondrial dysfunction and oxidative stress are the main drivers of OA pathogenesis 37

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