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A 2014 study in the Journal of Clinical Investigation confirmed kisspeptin as the mediator of sex steroid negative feedback to the hypothalamus in women

[DOI] [PubMed] Rinella ME, Neuschwander-Tetri BA, Siddiqui MS, Abdelmalek MF, Caldwell S, Barb D, et al

doi:10.1101/cshperspect.a009183 Acknowledgments This work was supported by the Chang Gung Memorial Hospital [Grants CMRPD1A0531, CMRPD1C0231, CMRPG391311, CMRPG3A1131] and the Ministry of Science and Technology, Taiwan [Grant NMRPD181001-3]

How do NR and NAD+ supplements affect energy levels and aging

Most protocols recommend taking time off after a cycle to allow the body to reset

Sindwani et al., 2019)
