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While data from a RCT controls for many of the potential confounding factors, using data from non-primary endpoints requires caveats

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Ethics statement The animal study was approved by The Committee on the Use of Live Animals in Teaching and Research (CULATR) of the University of Hong Kong (CULATR Ref

HirschSPoniachickJAvendaoMCsendesABurdilesPSmokGet al

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Interplay EpCAM with cytokines As mentioned above, the two most important cytokines, IL-6 and IL-8 (CXCL8/IL-8), are involved in various spectrum cellular pathways responsible for the proliferation, metastasis, or tumor cell survival
