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Kinnari PJ, Hyvnen ML, Mkil EM, Kaasalainen MH, Rivinoja A, Salonen JJ, et al

Helps to support healthy brain and cognitive function in older adults

Deficiency leads to nerve damage (neuropathy), which presents as numbness, tingling, or weakness

Abbreviations ASD: Autism spectrum disorder C1: One-carbon CFD: Cerebral folate deficiency CNS: Central nervous system DA: Dopaminergic FOLH1: Folate hydrolase 1 FR: Folate receptor FR: Folate receptor FR: Folate receptor FR: Folate receptor FRAAs: Folate receptor autoantibodies bFRAAs: Blocking autoantibodies to folate receptor GPI: Glycosylphosphatidylinositol MTHFR: Methylenetetrahydrofolate reductase 5-MTHF: 5-Methyltetrahydrofolate NMDA: N-methyl-D-aspartate Pax3: Paired box 3 PCFT: Proton-coupled folate transporter RFC: Reduced folate carrier SCF: Cerebrospinal fluid TRP/TRPM: Transient receptor potential superfamily, melastatin-related subfamily References Saitsu H (2017) Folate receptors and neural tube closure

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