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This helped to show that NNMT is a key target in metabolic research. Neelakantan and colleagues then expanded research involving small-molecule NNMT inhibitors

Intrinsic factor, produced by parietal cells in the stomach lining, binds to free b12 and enables absorption in the terminal ileum

Another study that included 256 children showed that those with a deficiency of vitamin B12 had a higher than average body mass index

When relief is partial, the next step is usually mechanism-based refinement rather than simply declaring treatment failure

It works by inhibiting NNMT, which may affect cellular energy metabolism and fat storage pathways

Kaji, T