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No significant hepatotoxicity, nephrotoxicity, or CNS effects were observed at therapeutic doses

Treatment strategies are tailored to disease severity and location and may include corticosteroids for acute flares, immunomodulators like azathioprine for maintenance, and biologic therapies targeting TNF- or integrins for moderate to severe disease

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PDK is an emerging target for the treatment of MetS which may allow the maintenance of the steady-state concentration of adenosine triphosphate during the feed-fast cycle