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Further studies are warranted to investigate its effectiveness as an adjuvant treatment during the early stages of infection (approximately 3 weeks), prior to the onset of pathological necrosis

Notably, the use of antibiotics is contraindicated in these patients, as it can increase the release of toxin from dying bacteria and worsen the clinical course

Figure 2 3.1.1 Preclinical foundations and mechanisms Preclinical studies in animal models have established the foundational rationale for this approach

The immune system in pregnancy: a unique complexity

The lack of GPX1 has also been implicated in a higher level of apoptosis (Crack et al., 2001