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At present, the exact mechanism by which heavy metal exposure/environmental factors induce epigenetic modifications is not known

However, under oxidative stress or pathological conditions like AGEs (72), Nrf2 is activated and translocated to the nucleus, initiating the expression of antioxidant genes such as GPX4, which are essential for reducing lipid peroxidation and delaying ferroptosis (73)

Control of lipid oxidation during exercise: role of energy state and mitochondrial factors

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Dosing Protocol A suggested daily injection approach based on common reference doses

Eur J Pharmacol (2016) 778:4455