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2.2.3 Key regulatory networks The tumor suppressor p53 can transcriptionally repress SLC7A11 expression, diminishing cystine uptake, curtailing GSH synthesis, and thereby promoting ferroptosis (28)

In this study, we demonstrated that GSSG accumulation induced by either H 2 O 2 exposure or GR inhibition suppressed TNF-induced NF-B activation

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5.5 Effects of statins on immunotherapies in HCC Recently, although statins have already been applied in other non-HCC cancers as adjuncts of immunotherapy, and obvious benefits have been attained, such applications in the clinical treatment of HCC are still lacking

Ozonation of antidepressant fluoxetine and its metabolite product norfluoxetine: kinetics, intermediates and toxicity

This circuit is ideal for those who want to have an overview of the citadel before embarking on the hike to the Great Cavern