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Lastly, while genomic and transcriptomic analyses have identified numerous resistance-associated genes, their functional roles remain speculative, highlighting the need for gene knockout or overexpression studies to validate their contributions ( 6 Drug pipeline advances in leishmaniasis Significant global efforts are driving advancements in the leishmaniasis drug pipeline, with clinical trials aiming to refine treatments, enhance prevention strategies, strengthen immune responses, and improve diagnostics These efforts span various forms of the leishmaniasis addressing challenges such as drug resistance, treatment adherence, and accessibility