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Structurally, the BBB consists mainly of endothelial cells of the cerebral capillaries, which are characterized by the presence of tight junctions that restrict the paracellular passage of molecules and by a notable absence of fenestrations and low pinocytic activity

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Our study suggests that decreased GTP levels may be a limiting factor in the functioning of Arl8b, Rab7, and other small GTPases

Furin most likely cleaves and activates more than 150 mammalian, viral and bacterial substrates

doi: 10.1126/scitranslmed.3007653

The Root Cause of Immunogenicity The immunogenicity of therapeutic antibodies often arises from their CDR (complementarity-determining regions)the regions responsible for antigen binding