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The contraindications are due to health concerns

Vegetarians, vegans, older adults, and those with absorption issues like Crohns disease or celiac disease are at risk of B-12 deficiency

doi: 10.1016/j.beem.2005.07.004

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J Biol Chem 248(19):68546861 Cavallini M, Casati A (2004) A prospective, randomized, blind comparison between saline, calcium gluconate and diphoterine for washing skin acid injuries in rats: effects on substance P and beta-endorphin release

More recently, however, researchers have considered the potential applications of specific antioxidants, more specifically NAC and GSH, to assist in the management of these respiratory complications