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DISCERN involves culturing fibroblasts from a skin biopsy and assessing multiple molecular signatures

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The SOD1 G93A mutation results in its accumulation within axons and significantly impedes mitochondrial trafficking
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Recruitment of the CoREST transcription repressor complexes by Nerve Growth factor IB-like receptor (Nurr1/NR4A2) mediates silencing of HIV in microglial cells
