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However, we have noted that a 10-fold plasma TMAO increase, induced by L-carnitine supplementation, does not affect inflammatory markers (i.e., vascular cell adhesion molecule, intercellular adhesion molecule, L-selectin, P-selectin, C-reactive protein, tumor necrosis factor , and interleukin-6 [10]) and oxidative stress markers (unpublished)

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Administration of anti-hepatic encephalopathy drugs such as neomycin, lactulose, lactitol, branched chain amino acids, and rifaximin was permitted when the patients were already taking these drugs before the study, but we forbade starting the administration of these drugs during the study

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