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The full inclusion and exclusion criteria can be found in the online supplement

None of the above is a substitute for evaluation by a licensed clinician

To ease access to this resource, we made all the data sets and statistical analyses available via a web application with an interactive interface ( While temporal RNA-Seq data from control mice and mice deficient for circadian clock genes (total or kidney specific) have already been published (9, 48), temporal high-throughput proteomics analyses have been limited to the WT mouse liver (28, 49, 50), macrophages (30), SCN (31), and forebrain synapse (51)

Compatibility with conjugation reactions depends on the chemistry of the conjugation method used

doi: 10.1186/s13578-017-0165-3

This is believed to be a major mechanism of hepatic damage generated by acute acetaminophen poisoning