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Mechanistically, this involves Lipin-1 activation of PPAR co-activator 1A (PGC1A) to promote the transcription of fatty acid oxidation genes ( Drosophila , Torsin was shown to promote dissociation of the NEP1R1-CTDNEP1 phosphatase complex from the NE, resulting in Lipin exclusion from the nucleus ( Drosophila fat body cells

Subsequently, acetyl-CoA carboxylase (ACC) carboxylates acetyl-CoA into malonyl-CoA, which is the rate-limiting step

By blocking this enzyme, triglycerides are not converted into free fatty acids that can be absorbed, resulting in their excretion without digestion

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These findings suggest that L-Carnitine may serve as an effective ergogenic aid for professional athletes, with potentially greater benefits in endurance and strength sports