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Whether chronic morphine exposure induces constitutive activity of MOR, or whether this is widespread in the nervous system is therefore still uncertain, but if correct, the observation that constitutive MOR activity increases after chronic opioid exposure suggests an active confomational state of MORs that is evident even in the absence of bound ligand

The level of transcription and protease of GPX will affect the conversion of GSH to GSSG [20]

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They may look for signs of nervous system problems