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Vacuoles have a major role in autophagy and maintain a balance between biogenesis (production) and degradation (or turnover) for many substances and cellular structures

The bidirectional regulation of autophagy in different brain regions may exert a crucial role in the therapeutic effects of luteolin on depression, as autophagy is closely related to various cellular processes, including lipid metabolism and synaptic function

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Nature 510 , 397401 (2014)

HW wrote the first draft of the manuscript

ISSN:1530-6984