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For individuals following a plant-based or vegetarian diet, B12 IM injections may be a preferred method of supplementation, as plant foods do not naturally contain significant amounts of B12

This was triggered by the discovery of LRP5 loss-of-function mutations in patients with osteoporosis pseudoglioma syndrome (OPPG), a recessive disorder characterized by low bone mass and abnormal eye vasculature (Gong et al., 2001)

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Nov 6;159(4):70913