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Evidence have shown that the process of metabolic reprogramming can be regulated by the underlying genetic factors that drive tumorigenesis

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They not only identified Rho A as a target of the human epidermal growth factor receptor 2 gene (ErbB2) signaling pathway in cardiomyocytes but also found that blocking Rho A during heart regeneration (or mitotically induced heart stimulations) resulted in changes in neuregulin 1 (Nrg1), Vegfaa, or vitamin D, disrupting muscle regeneration

The included trials compared one of the following nutrients to each other or a placebo (or no treatment): selenium, vanadium, thiamine, niacin, biotin, folic acid, cobalamin, ascorbic acid (vitamin C), vitamin D, vitamin E, vitamin K, zinc, chromium, magnesium, or calcium

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doi: 10.3329/jsr.v12i1.42059 3