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This greatly restricts the usage of native C3 protein for pharmacological inhibition of Rho-signalling in most cancer cells

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10.1073/pnas.0914009107 80 RajaramP.SubramanianR

Our results suggest that ASD-linked susceptibility genes ultimately converge on common signaling pathways regulating synaptic function and propose that these points of convergence are key to understanding the pathogenesis of this disorder

Stimulation of NSF ATPase activity by alpha-SNAP is required for SNARE complex disassembly and exocytosis
