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doi: 10.1186/s12575-023-00224-z

D., Prud'homme R., Mol

Reductive carboxylation A process that occurs in some normal and cancer cells whereby -ketoglutarate proceeds 'backwards' through the tricarboxylic acid cycle, being reduced through the consumption of NADPH by isocitrate dehydrogenase in the non-canonical reverse reaction to form citrate

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However, a question remained - does MMA also promote tumor progression by having suppressive effects on anti-tumor immunity