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Although cystine starvation has been shown to induce oxidative stress, we did not observe any increase in soluble or lipid ROS production in cystine-starved cells (Fig

Kong J, Zhang Y, Liu S, et al

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Despite some reports on the similarities between senescence and eryptosis at the morphological level [67], intracellular Ca 2+ elevation [74], Ca 2+ -driven activation of Gardos channels [70], PS exposure [76], or ROS contribution [71], senescence of erythrocytes cannot be considered an RCD of these cells and should be clearly distinguished from eryptosis

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Excess B12 does not generally cause direct harm to the kidneys or liver in people with healthy organs