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On the other hand, PERK activation phosphorylates eIF2, reducing protein synthesis and promoting autophagy

74 Pyruvate kinase M2 (PKM2), in addition to promoting the shunt of glycolytic intermediates into the PPP, has been shown to transcriptionally promote the expression of the anti-apoptotic proteins Bcl-xL and Bcl-2

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Result Repeated intraperitoneal injections of nitroglycerin induced migraine-like behavior in mice Based on previous reports, we established a chronic migraine-like model in male mice by administering intraperitoneal injections of nitroglycerin at a dose of 10 mg/kg every other day(Fig