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When the mitochondrial membrane is enriched in cholesterol, it decreases the activity of the GSH transporter system [57]

In addition, studies have shown shorter TL to be associated with poorer response to certain psychotropic medications, and our previous work suggested shorter TL and higher telomerase activity (TA) predicts poorer response to Selective Serotonin Reuptake Inhibitor (SSRI) treatment

Nat Cell Biol 13(2):132141

doi: 10.1016/j.scitotenv.2018.03.315 56 WangZ.PeiY.YanW.LuL.ZhouB

In contrast to the synthesis, that occurs only intracellularly, the degradation or catabolic part of the GSH cycle, takes place partially extracellularly and partially inside cells

For pharmacological interventions, treatment of mice was initiated once the average tumour volume in the groups reached approximately 300 mm 3