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Abstract Although iron accumulates in brain regions impacted by neurodegenerative diseases such as Alzheimers and Parkinsons, how chronic elevated iron levels contribute to neuronal dysfunction remains unclear

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Other intermembrane proteins released into the cytosol such as cytochrome c and Smac/DIABLO, do not promote apoptosis because APAP-induced mitochondrial dysfunction and oxidant stress prevents any apoptotic signaling in hepatocytes [54, 55]