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As one would expect, high levels of Nrf2 or Nrf2-target genes are observed in KEAP1 knockout mice and give these animals resistance to xenobiotics toxicity [264]
Shimoda and E.I
doi: 10.1016/0028-3908(93)90029-3 228 PaulR.JacksonS.WardM.JoshiA.CastroA.YehF
Conversely, long-term exposure to high levels of 5-HT may also desensitize 5-HTs receptors, triggering IBS-C (12)
Flock M
doi: 10.2147/IJGM.S241099 37 BriceagICostacheAPurcareaVLCerganRDumitruMBriceagIet al
