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Of the human Betacoronavirus, including OC43, HKU1, SARS-CoV-1, and Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) [4]

These include the rule of exponents method, which uses maximum lifespan potential and brain weight to correct the exponent,15 liver blood flow,20 and correction for in vitro metabolic clearance.21 The method of choice will depend on the PK characteristics of the drug candidate and the data available for scaling

doi: 10.1016/j.crgsc.2021.100176 168 MukhopadhyayRKaziJDebnathMC

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