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3.3 TMAO and ESRD Building on the understanding of TMAOs role in CKD, we now delve deeper into its implications for ESRD, highlighting the potential pathways through which TMAO contributes to the complex health challenges faced by ESRD patients

Obviously it doesn't replace exercise and a good diet, and only provides a little extra at least for me, but it helps considering the slips in diet derived from our lifestyle

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PMID 34463268

The intervals themselves are free from signs of disease. His observations were later included in the definition of the periodic syndrome of childhood described by Wyllie and Schlesinger in 1933