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MT1/2 downregulation has been observed in benign prostatic hyperplasia (BPH), PC-3 cells, and malignant tissues of the human prostate

this metabolite regulates oxidative stress pathways and suppresses lipid peroxidation (Li et al., 2025)

from pathophysiology to treatment

Abraham N, et al

In summary, these experiments have reinforced the strategy of protecting the heart by targeting mitochondrial ion channels in early reperfusion or under other conditions of oxidative stress (e.g., during chronic cardiac disease progression)
