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Most studies were brief and used dosages within the upper consumption limits, even though no significant adverse effects were documented in the supplementation trials that were part of this analysis

Clin Exp Pharmacol Physiol 26(11):865869 Flora SJ, Pande M, Kannan GM, Mehta A (2004) Lead induced oxidative stress and its recovery following co-administration of melatonin or N-acetylcysteine during chelation with succimer in male rats

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Catechins have the ability to scavenge ROS directly or indirectly via chelation of redox-active metal ions, inactivate enzymes exhibiting prooxidant activity (iNOS), increase the activity of antioxidant enzymes (GPX, catalase, SOD), and inactivate transcription factors involving NF-B (Babu and Liu 2008)