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In mice, GDF-15 increases satiety and reduces food intake through actions in the central nervous system [99]

Further, to avoid the worsening of disease activity or quality of life following the drug tapering, a close monitoring of these patients should be conducted, i.e., by employing biomarkers of inflammation, such as fecal calprotectin in the case of IBD to predict a disease relapse after anti-TNF- withdrawal or de-escalation

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(2002), HCC patients had significantly increased serum levels of HGF than patients with chronic viral hepatitis C and cirrhosis

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