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We found RNS-mediated inhibition of PDHC and OGDC occurs during classical macrophage activation, driving significant rewiring of cellular metabolism over time

The accumulation of these tangles follows a stereotypical progression through brain regions involved in memory and cognition, such as the hippocampus and entorhinal cortex

When glutamate release exceeds glutamate uptake, the excess glutamate activates a large number of postsynaptic NMDA-Rs, resulting in the induction of excitotoxic neuronal death by allowing excessive Ca 2+ influx through the receptor-operated cation channels [73]

[DOI] [PMC free article] [PubMed] [Google Scholar] 18.Nd B.F., Snodderly D.M., Johnson E.J., Schalch W., Koepcke W., Gerss J., Neuringer M

Thus, overall, a very low level of CoQ in these mice appears to be associated with a lower oxidative stress state, most likely because of reduced mitochondrial ROS production

Rai et al