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Luc JG, Reddy RM, Corsini EM, Carrott PW, David EA, Fabian T, McCarthy DP, Okereke I, Oliver AL, Shemanski K, Turner SR, Vaporciyan AA, Antonoff MB

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For example, if the agents are more active at a low pH, tests done at neutral pH will not reflect biological reality and could lead to useful activities being missed

Confounding by indication is likely

Studies show that higher intracellular water levels improve strength, endurance, and overall performance, while dehydration leads to decreased power and muscle efficiency

Genetic studies using DHAR overexpression, knockdown, and/or knockout lines supported the physiological importance of DHARs in ascorbate recycling (Chen et al