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This concentration-dependent effect is epitomized in energy metabolism during exercise, where a shift from white adipose tissue to intramuscular triglycerides as the primary fatty acid source occurs as blood lactate rises from 2 mM to 5 mM, demonstrating lactates role as a metabolic rheostat in real-time [148]

A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide