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After many years of clinical trials, anti-VEGF agents appeared to be active as single agents only in a limited number of cancers, e.g

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With miotics, this was since the initial introduction of physostigmine and pilocarpine application [61,62], which was the mainstay of glaucoma treatment for 100 years, and is still in use [31,32,33,34]

In preclinical studies, BPC-157 demonstrated an exceptionally wide therapeutic window with no observed toxicity even at high doses. Sikiric et al., Current Pharmaceutical Design Long-Term Safety As of now, long-term human safety data is lacking