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Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia

This leads to carnitine accumulation within endothelial cells to stimulate FAO and energy production, which is necessary for maintaining inflammatory responses [88]

[DOI] [PubMed] [Google Scholar] 38.Arngrim N., Schytz H.W., Britze J., Amin F.M., Vestergaard M.B., Hougaard A., Wolfram F., de Koning P.J., Olsen K.S., Secher N.H., et al

Carnitine is synthesized by liver, kidney, and in smaller amounts by brain from methionine and protein bound lysine

Current evidence indicates a reassuring safety profile of L-carnitine in preterm infants, with no adverse effects observed across studies despite substantial variations in dosing regimens ( Statements Author contributions SM: Conceptualization, Writing original draft