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GSH has limited permeability through the blood-brain barrier(Haddad et al., 2021), a systemic isolation which might contribute to the stability of cerebral GSH levels with pathology(Haddad et al., 2021) and aging(Gong et al., 2022

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The four-week intervals at each dose level allow GI adaptation

Patients with active cancer, uncontrolled diabetes, or pituitary disorders should not use growth hormone secretagogues without direct specialist oversight