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In humans, IDO1 (hIDO1UniProt P14902) has 403 amino acids, is monomeric, and with the exception of the liver, is widely distributed and constitutively expressed in multiple different tissues in healthy conditions, including lungs, small intestine, lymphatic system organs, female reproductive organs and the placenta [127,128]

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There is a 5-fold increased risk of ototoxicity with cisplatin, which can manifest as tinnitus, high-frequency hearing loss, and, in the later stages, a decreased ability to hear normal conversation (24)

Rivastigmine: the advantages of dual inhibition of acetylcholinesterase and butyrylcholinesterase and its role in subcortical vascular dementia and Parkinsons disease dementia

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1a, b) binds to double-stranded telomeric repeats and mediates telomere protection, replication and extension 4,14