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This is more of a niche requirement and doesn't apply to IGF-1 LR3, but it's good to be aware of
Primary osteoblasts deficient in DHCR7 accelerate osteogenic differentiation by upregulating the expression of Col1a1 (osteogenic factor), while INSIG1/2-deficient cells have the opposite effect
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Insulin regulates the serum levels of low molecular weight insulin-like growth factor-binding protein
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doi: 10.1186/s12891-018-2339-5
