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This study was supported by a grant from the Second Affiliated Hospital of Fujian Medical University (Serial No
10.1016/j.cmet.2019.08.021 27 ChenY.WangM

While some subjects reported side effects such as nausea or other digestive problems, there were no serious problems

Nutrients (2020) 12:2982

This study found that N-acetylaspartate (NAA)/total creatine (tCr) and choline (Cho)/tCr levels changed in a time-phase-dependent manner in migraine (33)
Studies with the following criteria were excluded: described in languages other than English, articles without full-text availability, reviews and case reports