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In the skin, these reactive aldehydes act as secondary messengers in redox-sensitive pathways, including NF-B and Nrf2, thus influencing gene expression, protein modifications, and enzymatic activity, which are essential for maintaining epidermal integrity and function

The lancet oncology 22(10):1448-1457, 2021

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In contrast, 80% of both male and female mice displaying lymphoma signs before 6 months of age (Fig

reported that GLS-driven Gln metabolism is a regulator of radiotherapy tolerance in prostate cancer (PCa) and that high expression of GLS 1 and c-MYC, key regulators of Gln, are significantly associated with reduced progression-free survival in prostate cancer patients treated with radiotherapy