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In addition, increasing STAT3 from activated JAK/STAT signaling pathway might be involved in the apoptosis of cell through PTEN, which inhibits Akt cascade, resulting in exacerbated hyperglycemia 136 (Fig

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Upon stimulation by various inducers, NF-B undergoes translocation to the nucleus, where it binds to specific DNA sites and orchestrates the transcriptional control of numerous genes
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