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and ii) permeation Enhancers such as Dimethyl sulfoxide(DMSO), Dimethyl formamide, Ethanol, Propylene glycol, Octyl alcohol, Caprylocaproyl polyoxyl-8 glycerides and diethylene glycol monoethyl ether, Ethyl oleate, Isopropyl myristate , Glyceryl monolaureate, Silicone oil etc

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However, in FUS-induced ALS/FTD, FUS is hypomethylated and accumulates in neurons as both nuclear and cytoplasmic aggregates

Thus, despite the demonstrated senolytic effects of BCL-2 family inhibitors, their clinical translation is limited due to potential side effects, off-target effects on platelets and poor central nervous system (CNS) penetrance