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Overdoing it can occasionally lead to side effects like nerve irritation (with too much B6), skin flushing (from high-dose B3), or digestive upset

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[2] Oral B12 supplementation generally takes longer to produce effects , with patients often noticing energy improvements within two to four weeks

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Interestingly, it can take years for B12 stores to deplete to a point where a deficiency becomes apparent: Vitamin B12 deficiency affects multiple systems, and sequelae vary in severity from mild fatigue to severe neurologic impairment