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10.1042/BJ20061707 34 FedericiL.MasulliM.Di IlioC.AllocatiN

12,13 Thus, the canonical enzymatic activity of GS is present in many tissues and cell types and is likely subject to different GS regulatory needs

NSCs, Neural Stem Cells

Recently studies suggest that lysine lactylation has mechanistic similarities with lysine acylation, which has been studied extensively since the 1960s ( L-la is tightly regulated by these enzymes, which can install and remove the L-lactyl groups rather than the acetyl group to lysine residues (Sung et al., 2023

doi: 10.1007/s00216-006-0529-8 105 HuangYWangQGaoJLinZBauelosGSYuanLet al

In endothelial cells, nitric oxide (NO) was found to protect against H 2 O 2 -induced toxicity via induction of GCLC that required the participation of zinc and Nrf2 [89]