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674 The 9,10- and 12,13-DiHOMEs also induced renal proximal tubule cell death associated with mitochondrial dysfunction, while the corresponding epoxide did not induce cell death at concentrations up to 1 mM

What I've learned, and I've had to learn this over time, and I think the wisdom is-- and this is why it's even more challenging, because I think people go on social media, and they listen to podcasts and they listen to influencers, and a lot of the messages is additive

They reported that CHE inhibited cell proliferation by triggering mitochondrial apoptosis through the PI3K/BAD signaling pathway, significantly increasing the activated expression of the BAD protein, upregulating the proapoptotic proteins BAX and BAK, and downregulating the antiapoptotic proteins BCL-2 and MCL-1 (Yang et al., 2020)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 57.de Gooijer MC, Kemper EM, Buil LCM, itirikkaya CH, Buckle T, Beijnen JH, van Tellingen O

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