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The conversion of glucose to fructose involves the polyol pathway where glucose is first reduced to sorbitol via the action of the aldose reductase encoded by the AKR1B1 (aldo-keto reductase family 1 member B) gene

Du N, Yang R, Jiang S, Niu Z, Zhou W, Liu C, Gao L, Sun Q (2024) Anti-aging drugs and the related signal pathways

The trial will measure the number of patients in each arm whove achieved at least 25% or 30% weight reduction at the end of treatment

While results have been promising, further research is necessary to establish clear guidelines on dosage and administration for optimal kidney protection

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