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Second, like all proteins neurotrophic factors are susceptible to degradation by proteases and hence require chronic dosing methods

McCarty MF, Lerner A

SCC-containing papain/urea ointments are still available in the US by prescription (42)

Bayot ML, Tadi P

T., Pires M

Several small RCTs and a meta-analysis indicate that botulinum toxin injections improve pain and overall foot function at three and eight weeks in patients with plantar fasciitis
